This Week in Chronic Pain Management News

Week of March 13, 2019

NDA for Novel Migraine Treatment Ubrogepant Accepted for FDA Review
EMPR: “Allergan announced that the Food and Drug Administration (FDA) has accepted for review the New Drug Application for ubrogepant, a highly potent oral calcitonin gene-related peptide (CGRP) receptor antagonist, for the acute treatment of migraine in adults.” Click here for full story.

Asthma and Allergies May Be Associated With Rheumatoid Arthritis
Rheumatology Advisor: “Associations may exist between asthma, allergies and rheumatoid arthritis, according to a study recently published in Arthritis & Rheumatology. Rheumatoid arthritis does not appear to be associated with passive exposure to smoke.” Click here for full story.

Navigating Effective Approaches to Migraine Treatment for the Underinsured
Clinical Pain Advisor: “Despite the availability of new therapies, the vast majority of people with migraine headache receive inadequate treatment. A 2013 study by Lipton et al1 proposed 3 steps to achieving minimally effective pharmacologic therapy for acute and chronic migraine.” Click here for full story.

5 Myths About Endometriosis Busted By An Expert, Because Accurate Information Is Crucial
Bustle: “Unfortunately there are many myths and misconceptions about endometriosis. There’s currently very little education in schools about the condition, and the fact that it can be quite complex to diagnose and treat doesn’t help. But correct information can be life-changing for those living with the condition.” Click here for full story.

Migraine Linked to Distorted Neural Connections
AJMC: “According to a recent study, people with migraines may have altered connections between the somatosensory cortex and the frontal lobe compared with people who do not experience migraines.” Click here for full story.

What to Know About Back Pain in Pregnancy
Medical News Today: “Along with nausea, fatigue, and swollen feet, most women experience back pain at some points during pregnancy. Pregnancy-related back pain typically affects the lower back.
According to one review that looked into the complaint, low-back pain affects more than two-thirds of women during pregnancy.” Click here for full story.


Week of February 27, 2019

Surprise Rheumatoid Arthritis Discovery Points to New Treatment
Science Daily: “Researchers have identified an unexpected contributor to rheumatoid arthritis that may help explain the painful flare-ups associated with the disease. The discovery points to a potential new treatment for the autoimmune disorder and may also allow the use of a simple blood test to detect people at elevated risk for developing the condition.” Click here for full story.

Melatonin Supplements May Help Treat Fibromyalgia by Aiding Mitochondria, Animal Study Finds
Fibromyalgia News Today: “Melatonin, an antioxidant, may be beneficial in treating imbalances in the mitochondria of people with fibromyalgia, a complication known as mitochondrial dysfunction, a study in rats with fibromyalgia-like chronic pain symptoms reports.” Click here for full story.

3 Ways CBDs Can Provide Endometriosis Relief
Care2: “The therapeutic potential of CBDs is incredibly promising. Thanks to the discovery of our body’s innate endocannabinoid system, we’ve learned that CBDs can soothe and balance our most important bodily systems, like our reproductive system. In fact, they may be able to provide some much-needed relief for chronic women’s hormonal conditions, like endometriosis.” Click here for full story.

Identifying Barriers to Care for Women With Endometriosis
Medical Xpress: “Women face a multitude of barriers to receiving quality care for endometriosis, a chronic, often painful disease that affects approximately 10% of reproductive-age women, an estimated 200 million women and teens worldwide.” Click here for full story.

Week of February 20, 2019

Multispecies Probiotics May Be Effective in Chronic, Episodic Migraine
Clinical Advisor: “A probiotic mixture supplement may be effective for reducing the frequency and severity of migraine attacks and the use of abortive drugs in patients with chronic and episodic migraine, according to a study published in Cephalalgia.” Click here for full story.

FDA Accepts Upadacitinib New Drug Application for Rheumatoid Arthritis
MD Magazine: “Investigational daily oral therapy upadacitinib is a step closer towards marketing indication as a rheumatoid arthritis (RA) treatment. The U.S. Food and Drug Administration (FDA) has accepted and granted Priority Review to AbbVie’s New Drug Application (NDA) for upadacitinib as a therapy for adult patients with moderate to severe RA.” Click here for full story.

Lupus Strongly Linked to Imbalances in Gut Microbiome
EurekAlert: “The disease systemic lupus erythematosus (SLE) — marked by the attack on joints, skin, and kidneys by the body’s immune system — is linked to an abnormal mix of bacteria in the gut. This is according to a new study led by scientists at NYU School of Medicine.” Click here for full story.

Startup Seeks to Test for Endometriosis Through Period Blood
Jezebel: “Sometime in the not-too-distant future, people worried about their fertility and reproductive health may be able to test for endometriosis, along with numerous other disorders, simply by sending a used tampon to a lab.” Click here for full story.


Week of February 6, 2019

Scientists Identify Reversible Molecular Defect Underlying Rheumatoid Arthritis
Medical Xpress: “In rheumatoid arthritis, immune cells called helper T cells behave differently from their counterparts in healthy cells and in other autoimmune diseases. Stanford scientists have learned why… Stanford University School of Medicine investigators succeeded in countering inflammation and tissue damage caused by rheumatoid arthritis in mice engrafted with human joint-lining tissue and a human immune system.” Click here for full story.

Finding a Fibromyalgia Doctor
Harvard Health: “It’s not uncommon for people with fibromyalgia to encounter doctors who don’t understand fibromyalgia, don’t know how to diagnose and treat it, or simply don’t believe it’s a real condition… These tips on finding the right fibromyalgia doctor may help:” Click here for full story.

New Research Further Explores Alcohol’s Role as a Migraine Trigger
Neurology Advisor: “Researchers have found that alcohol, and specifically red wine, is a potent migraine trigger in patients with migraine. Many patients with migraine avoid or drastically reduce their alcohol consumption based on its triggering effects. The findings from this observational study were published in the European Journal of Neurology.Click here for full story.

Slow Fetal Growth, Low Birth Weight May Point to Endometriosis Later in Life, Study Suggests
Endometriosis News: “Slow fetal growth during pregnancy and low birth weight are linked to a higher risk of endometriosis later in life, a study suggests. The study, ‘Developmental origins of endometriosis: a Swedish cohort study,’ was published in the Journal of Epidemiology & Community Health.Click here for full story.

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